Endocytosis (IMAGE) Cold Spring Harbor Laboratory Caption After coated vesicles pinch off from the plasma membrane, a rapid uncoating reaction, shown here, disassembles the clathrin scaffold and releases a nascent endocytic vesicle that will fuse with endosomes and deliver its cargo for further sorting along the endosomal/lysosomal pathway. Prepared by Janet Iwasa and Tom Kirchhausen, Department of Cell Biology, Harvard Medical School. Credit ©2014 Cold Spring Harbor Laboratory Press Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.