A Polymorphic p53 Response Element in KITLF (IMAGE)

Cell Press

A Polymorphic p53 Response Element in KITLF

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One of the most important proteins implicated in cancer is p53, which binds to DNA to regulate the activity of a large number of genes. In a study published by Cell Press October 10th in the journal Cell, researchers have identified a DNA sequence variation in a p53-binding site that is more prevalent in Caucasians than in Africans and is associated with a very large risk of testicular cancer but may protect light-skinned individuals against harmful ultraviolet rays. The study offers novel insights into the evolution of DNA sequence variations in p53-binding sites, and it could also lead to improvements in personalized treatment strategies.

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<i>Cell</i>, Zeron-Medina et al

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