A Plier-Like Gripe (IMAGE) Rockefeller University Caption Two activated STAT3 molecules surround DNA (center). Previously, efforts to interfere with STAT3's contribution to cancer have focused on interactions between the SH2 domains (yellow) at the tip of the pliers. Darnell and his team instead altered the linker domains (orange). Credit Laboratory of Molecular Cell Biology at The Rockefeller University/PNAS Usage Restrictions Image may be used only to illustrate the research described in the accompanying release. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.