Targeting Alzheimer's Enzyme without Affecting Normal Function (IMAGE)

Cell Press

Targeting Alzheimer's Enzyme without Affecting Normal Function

Caption

This visual abstract depicts how Ben Halima et al. demonstrate the feasibility of designing drugs targeting the Alzheimer-related enzyme BACE1 without affecting its physiological function. Using structural, biochemical, and cellular approaches, they show that BACE1 inhibitors can be designed to specifically inhibit its disease-causing activity, enhancing their potential as therapeutics without undesired side effects.

Credit

Ben Halima et al./<i>Cell Reports</i> 2016

Usage Restrictions

Credit Required.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.