Same Place, Same Time (IMAGE) Rockefeller University Caption The neurotransmitters acetylcholine and glutamate were known to play a role in nicotine dependence. The orange region above shows the overlap of these neurotransmitters in the habenular circuit, where they interact to reinforce addiction. Credit Laboratory of Molecular Biology at The Rockefeller University Usage Restrictions Image may only be used to illustrate the research described in the accompanying release. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.