MutL Animation (VIDEO) McMaster University This video is under embargo. Please login to access this video. To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Caption The three-dimensional structure of MutL is presented as a ribbon diagram with the metal-binding and endonuclease sites labeled. The electrostatic surface of MutL reveals that the region surrounding the active site (endonuclease site) is predominantly negatively charged. Since DNA is also negatively charged, MutL-DNA binding is impaired by charge repulsion. Credit Faculty of Health Sciences McMaster University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.