Histology and <i>in vitro</i> Model (IMAGE) Heinrich-Heine University Duesseldorf Caption Histological section of a liver biopsy of a healthy individual (upper left) and an NAFLD patient (upper right) (1). Lipid droplets are visible as vacuoles. Induced pluripotent stem cells, which express the pluripotency marker OCT4 (middle left, green), are in vitro differentiated into hepatocyte-like cells, characterized by the expression of ALBUMIN (ALB, middle right, red) and alpha-fetoprotein (AFP, middle green right). Unstimulated in vitro derived hepatocyte-like cells do not incorporate lipid droplets (lower left) while they develop massive lipid droplets after stimulation with oleic acid (lower right, green). Credit Graffmann N et al. Usage Restrictions Only by permission of authors. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.