Oncogenic lncRNA FAL1 (IMAGE) University of Pennsylvania School of Medicine Caption This image depicts an oncogenic lncRNA FAL1 (the dragon) dysregulating gene transcription and promoting tumorigenesis. FAL1 stabilizes BMI1 (the stone) by associating with it (the dragon twine around the stone), which subsequently enhances the activity of PRC1 (the stone pile). Constant information flow from DNA to mRNA (the water stream) is essential for normal cell growth. Inhibition of transcription (blockade of water) on tumor suppressor genes, such as p21, leads to cell transformation (growth of the cactus-like eremophytes instead of normal plants from the drought). Credit Artwork by Lili Guo Usage Restrictions Please credit the artist. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.