ALS Disease Protein (IMAGE) University of Pennsylvania School of Medicine Caption Whole-brain density map of TDP-43 distribution throughout central nervous system of ALS patients. Red, orange, and yellow depict areas of highest density of TDP-43 pathology. Credit Felix Geser and Nick Brandmeir, University of Pennsylvania; Archives of Neurology Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.