Centromere Stabilization (IMAGE) University of Pennsylvania School of Medicine Caption The direct binding of CENP-C to the CENP-A nucleosome stabilizes hydrogen bonding within internal secondary structures of the CENP-A nucleosome. Stars indicate fluorescent probes that move closer to each other upon CENP-C binding, as a result of CENP-C altering the shape of the CENP-A nucleosome into a more rigid and stable conformation. Credit Lucie Guo and Ben Black, Perelman School of Medicine, University of Pennsylvania Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.