Centromere Stabilization (IMAGE)

University of Pennsylvania School of Medicine

Centromere Stabilization

Caption

The direct binding of CENP-C to the CENP-A nucleosome stabilizes hydrogen bonding within internal secondary structures of the CENP-A nucleosome. Stars indicate fluorescent probes that move closer to each other upon CENP-C binding, as a result of CENP-C altering the shape of the CENP-A nucleosome into a more rigid and stable conformation.

Credit

Lucie Guo and Ben Black, Perelman School of Medicine, University of Pennsylvania

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