ATIII Conformational Changes (IMAGE) University of Massachusetts Amherst Caption Cleavage of active ATIII by the target proeteases (cyan) leads to the formation of a covalent bond between ATIII and the protease, and a large conformational change that helps to distort and inhibit the protease. Credit UMass Amherst Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.