Snake Graphic (IMAGE)
Caption
The new study provides evidence that proteins linked to more severe forms of ALS are less stable structurally and more prone to form clusters or aggregates. Mutants of the superoxide dismutase (SOD) protein formed long, rod-shaped aggregates (shown here as red lattice), compared to the compact folded structure of wild-type SOD (purple ribbons).
Credit
Image courtesy of the Getzoff and Tainer labs, The Scripps Research Institute.
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