TB Infection in Normal and Mutated Zebrafish (IMAGE)

University of Washington

TB Infection in Normal and Mutated Zebrafish

Caption

These zebrafish larvae are infected with fluorescently labeled bacteria related to those that cause tuberculosios in humans. The wildtype (normal) fish has optimal inflammation and is able to control infection. In contrast, its siblings have been altered to produce either low or high levels of key mediators of inflammation. Either too little or too much production of these mediators results in difficulty in controlling the infection.

Credit

Francisco Roca

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