Liver Fat Gets a Wake-Up Call (IMAGE) University of Pennsylvania School of Medicine Caption This image shows a high-fat-diet (HFD)-induced fatty liver in wild-type mice, characterized by big lipid droplets in liver cells (top). Liver-specific HDAC3 knockout mice on HFD, note that the lipid droplets become smaller even though the total lipid content is increased (bottom). Credit Mitchell Lazar, M.D., Ph.D.; Zheng Sun, Ph.D., Perelman School of Medicine, University of Pennsylvania; <i>Nature Medicine</i> Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.