An AIDS-Related Virus Tricks Cells to Become Tumors (IMAGE)

University of Pennsylvania School of Medicine

An AIDS-Related Virus Tricks Cells to Become Tumors

Caption

The viral protein recruits cellular proteins complexes made for ubiquitination of specific substrates like VHL and p53. Once the Ub portion is attached to the substrates they are then recognized and degraded by the cellular 26S proteasome system.

Credit

Erle Robertson, Ph.D., University of Pennsylvania School of Medicine

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