T-Tubule Network in Heart Muscle (IMAGE) University of Iowa Health Care Caption UI study shows that T-tubule disruption starts to occur even before any decline in heart function is detectable. The study also finds that T-tubule disorganization gradually worsens over the progression of heart disease and correlates with the severity of cardiac hypertrophy and predicts heart function. Understanding how T-tubule disruption occurs may lead to new ways to diagnose or treat heart failure. Credit University of Iowa Usage Restrictions Image may be used only for education/media purposes. Please use appropriate credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.