Contact: Paul Preuss
paul_preuss@lbl.gov
510-486-6249
DOE/Lawrence Berkeley National Laboratory

Mre11 Bound to DNA

Caption: Mre11 proteins initiate the repair of double-strand breaks in DNA, either on two ends of broken DNA brought together (synaptic complex at left) or at the site of a collapsed fork in replicating DNA (branching complex at right). The detailed structural information in these models was mostly obtained from protein crystallography of Mre11 dimers bound to DNA.

Credit: Williams, Tainer et al, Lawrence Berkeley National Laboratory and Scripps Research Institute

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Related news release: The structure of the Mre11 protein bound to DNA