Contact: Tara A. Ellis
tellis@hwi.buffalo.edu
716-898-8596
Hauptman-Woodward Medical Research Institute

Dr. Debashis Ghosh, Hauptman-Woodward Medical Research Institute

Caption: "This is a dream come true," Dr. Debashis Ghosh, an HWI senior research scientist and a principal investigator who also holds a joint faculty appointment at the Roswell Park Cancer Institute , said. "Scientists worldwide have been trying for 35 years to crystallize this membrane-bound enzyme and we are the first to succeed. Now that we know the structures of all three key enzymes implicated in estrogen-dependent breast cancers, our goal is to have a personalized cocktail of inhibitors customized to the specific treatment needs of each patient. Our knowledge about these three enzymes will enable us to develop three mutually exclusive inhibitors customized to each patient's needs which will work in harmony together with minimal side effects."

Credit: Gloria J. DelBel

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Related news release: HWI scientist first in world to unravel structure of key breast cancer target enzyme