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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Editing Errors

Caption: When B cells produce antibodies, self-binding or anti-self antibodies are often formed (red-colored cells). Such anti-self cells must be eliminated, either by cell death or by revising the specificity of the antibody through a process called receptor editing. When successful, receptor editing produces a B cell that is non-self binding (green-colored cell). The Penn study documented lower levels of antibody gene rearrangements in B cells from some patients with autoimmune disease, suggesting a defect in this early B-cell tolerance checkpoint.

Credit: Nina Luning Prak, M.D., Ph.D, Univeristy of Pennsylvania School of Medicine

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Related news release: Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus


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