Contact: Gina Kirchweger
Caption: In aging cells one of the proteins composing nuclear pores becomes damaged and molecules that should be restricted to the cytoplasm invade the nucleus (outline shown in red). In particular, a protein called tubulin (shown in green), which is strictly a cytoplasmic protein, shows up as long filaments that co-opt a large part of the nucleus.
Credit: Courtesy of Dr. Maximiliano D'Angelo, Salk Institute for Biological Studies.
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