Development of Autoimmune Inflammation Can Be Followed with Increasing Age in Individual Mice (image) American Journal of Pathology Share Print E-Mail Caption Upon inflammation, a transcription factor (NF-kB) activates the translation of a firefly protein (Luciferase) generating photons in cells of diseased tissues. The technique is highly sensitive and predicts development, severity and outcome of disease. Top: Skin disease with gradual involvement of ears and snout. Middle: Arthritis development, light signals appear several weeks before clinical signs. Bottom: Development of inflammatory signals from the intestines (inflammatory bowel disease, and perianal inflammation). Credit Zangani et al, Am J Pathol, 2009 Usage Restrictions None, as long as source is referenced Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.