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Contact: Jennifer Brown
University of Iowa

CATSPER1 Gene and Male Infertility

Caption: Mouse studies have shown that the CATSPER1 gene is present in sperm and is essential for normal sperm motion during fertilization. The left side of the diagram illustrates normal sperm fertilizing an egg. The right side of the diagram illustrates that sperm lacking the CatSper1 protein are not able to penetrate an outer layer of the egg, known as the zona pellucida, preventing normal fertilization.

Credit: University of Iowa. Image adapted from Avenarius et al 2009 AJHG in press.

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Related news release: Gene discovery could lead to male contraceptive

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