Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania

Multicellular Architecture Regulates Cellular Function (2 of 2)

Caption: Immunofluorescence sections of cells embedded within a micropatterned collagen gel. Cells generate forces within a tissue that can feedback to regulate the accumulation of cytoskeletal proteins such as actin (green) and structural matrix proteins such as fibronectin or tenascin C (red) in a spatially dependent manner. Cell nuclei are labeled in blue.

Credit: Image courtesy of Wesley R Legant

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