Contact: Barbara K. Kennedy
Caption: This chart shows the type of data used in a multi-scale wavelet analysis as part of research that has shed light on genetic processes that lead to certain human DNA mutations implicated in hundreds of inherited diseases. Both lines on thisd chart indicate the frequency of recognition sites for the enzyme topoisomerase. The black line represents the frequency of topoisomerase recognition sites surrounding deletions and the green line represents the frequency of recognition sites surrounding normal DNA. The figure demonstrates the team's finding that there are patterns in the DNA sequences immediately surrounding deletions and insertions -- in this case an increased frequency of topoisomerase recognition sites around deletions.
Credit: Penn State University, Kateryna Makova research lab
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