Contact: James Newton
james.newton@childrens.harvard.edu
617-355-6420
Children's Hospital Boston

Nicotinamide Alleviates MS-Like Disease in Mice

Caption: In mice with MS-like disease, nicotinamide delayed and reduced neurologic disability as indicated by behavioral scores (1 indicating mild weakness only in the tail; 4, paralysis involving all four limbs). Mice receiving placebo (saline) had the most disability, while mice receiving high-dose nicotinamide had the least. Wlds mice (which more readily convert nicotinamide to NAD) benefited most from treatment.

Credit: Courtesy Shinjiro Kaneko, MD, Neurobiology Program, Children's Hospital Boston

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