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Tracking Chromosome Missegregation

Caption: Thompson and Compton introduced a single fluorescent mark into the genome of a diploid cell line, induced missegregation, and identified the cells that incorrectly carried two or zero marks (green) on their DNA (blue). These cells arrested due to increased levels of the tumor suppressor p53 (purple) and its transcriptional target, the cyclin-dependent kinase inhibitor p21 (red).

Credit: Thompson, S.L., and D.A. Compton. 2010. J. Cell Biol. doi:10.1083/jcb. 200905057.

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