Contact: Sandra Szivos
sasz@sund.ku.dk
453-532-6921
University of Copenhagen

Model of the Findings: Naïve T Cells Do not Express Vitamin D Receptor nor Plc-Gamma1

Caption: When the naïve T cell recognizes foreign molecules with its T cell receptor (TCR) it sends activation signals (1) to the VDR gene. The VDR gene now starts the production of VDR (2). VDR binds vitamin D in the T cell (3) and becomes activated. Vitamin D bound to activated VDR goes back into the cell nucleus and activates the gene for PLC-gamma1 (5). PLC-gamma1 is produced (6) and the T cells can get started.

Credit: Professor of Immunology, Carsten Geisler

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