Contact: Kat Snodgrass
Society for Neuroscience
Caption: This pair of time-lapse movies show mitochondria moving along nerve cell fibers. In the first clip, mitochondria with normal mitofusin proteins move quickly along the fiber. In this second clip, mitochondria with a mutant form of mitofusin 2 are smaller and move slowly. This abnormal movement is thought to be the basis for the neurodegenerative disease Charcot-Marie-Tooth type 2A.
Credit: Courtesy, with permission: Misko et al. The Journal of Neuroscience 2010.
Usage Restrictions: For reporters, free use with appropriate credit line. All others, please contact The Journal of Neuroscience.
Related news release: Disease-causing mutation disrupts movement of cell's 'power house'