This pair of time-lapse movies show mitochondria moving along nerve cell fibers. In this clip, mitochondria with normal mitofusin proteins move quickly along the fiber. In the second clip, mitochondria with a mutant form of mitofusin 2 are smaller and move slowly. This abnormal movement is thought to be the basis for the neurodegenerative disease Charcot-Marie-Tooth type 2A.
For reporters, free use with appropriate credit line. All others, please contact The Journal of Neuroscience.