Contact: Jules Asher
NIH/National Institute of Mental Health
Caption: To receive a reward, a mouse in the T-maze had to remember whether it had turned left or right on the previous trial, and turn in the opposite direction. Mice genetically engineered to lack a specific segment of genetic material on Chromosome 22, a known cause of schizophrenia -- like patients with the disorder -- faltered at such working memory tasks, because of poor functional connections between the brainís executive and memory hubs.
Credit: Torfi Sigurdsson, PhD, Department of Psychiatry, Columbia University
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