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Mystery of the Migrating T Cell (1 of 2)

Caption: This is an artist's rendition of a T cell caught in the act of egress from the thymus. Newly generated T cells leave the thymus and become part of the peripheral immune system by reverse transmigrating into blood vessels. Red colored cell represents an emigrating T cell labeled by intravenous injection of fluorophore-conjugated antibody. Blood vessel is in blue, and packed white nuclei (spheres) indicate cortex whereas dispersed white nuclei indicate medulla. This image relates to an article that appeared in the April 22, 2010, issue of Science Express, published by AAAS. The study, by Dr. Marcus A. Zachariah and Dr. Jason G. Cyster of Howard Hughes Medical Institute and University of California, San Francisco, was titled, "Neural Crest-Derived Pericytes Promote Egress of Mature Thymocytes at the Corticomedullary Junction."

Credit: Image courtesy of Jessica Huppi

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