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Accumulation of Defective Mitochondria

Caption: Parkin (green) promotes the turnover of damaged mitochondria (red, left), but defective organelles accumulate near the nucleus if Parkin lacks its ubiquitin ligase activity (right).

Credit: Lee, J.-Y., et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001039.

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Related news release: Mutations that cause Parkinson's disease prevent cells from destroying defective mitochondria


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