Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Caption: The insulin-secreting beta cells (green) normally exhibit a perinuclear cap of proinsulin (orange in left panel) whereas proinsulin is spread throughout the cytoplasm (orange in right panel) in many beta-cells of PERK-deficient mice, which are diabetic because of insufficient secretion of insulin.
Credit: Wei Zhang, Penn State
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