Contact: Ingrid Benirschke
benirsch@cshl.edu
619-275-6021
Cold Spring Harbor Laboratory

Epigenetics

Caption: Depicted is a schematic representation of the chromatin template. Epigenetic regulation affects and modulates this template through noncoding RNA (ncRNA) that associate with it, covalent modification of histone tails (mod), methylation of DNA (Me), remodeling factors (blue oval), and nucleosomes that contain standard as well as variant histone proteins (the yellow nucleosome). In the background is a representation of several model organisms in which epigenetic control has been studied. From top left: Pair of mouse chromosomes that may differ in their genomic imprint; a S. cerevisiae colony, showing epigenetically inherited variegation of gene expression; anatomy of C. elegans; illustration of T. thermophila, showing the large "active" macronucleus and the smaller "silent" micronucleus; D. melanogaster; maize selection with kernel color variegation; Arabidopsis flower.

Credit: (c) 2007 by Cold Spring Harbor Laboratory Press

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