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Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
Caption: Botulinum neurotoxin hijacks synaptic vesicle recycling at neuromuscular junctions. The toxin first docks to the active zone (blue) by binding to two membrane-anchored receptors, synaptotagmin (red) and ganglioside (yellow). The toxin-receptor complexes are then internalized by endocytosis.
Credit: Courtesy of Axel Brunger/HHMI at Stanford University
Usage Restrictions: Must contact the HHMI Communications Office for permission to reprint. 301-215-8858 or keeleyj@hhmi.org
Related news release: Seeing a neurotoxin's deadly grip
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