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Contact: Natalie Bouaravong
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415-568-3445
Public Library of Science
Caption: HIV Tat transactivates its own expression, but this requires conv ersion from deacetylated Tat (TatD) to acetylated Tat (TatA), a reaction that establishes a feedback resistor and allows the circuit to shut off.
Credit: Image: Weinberger et al.
Usage Restrictions: Please cite the authors and PLoS Biology as the source.
Related news release: A simple feedback resistor switch keeps latent HIV from awakening
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