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Caption: This figure shows the cells in the blood of mice used in this experiment, viewed though a microscope. White blood cells have been stained dark purple to make them more visible. The left panel shows blood from a normal mouse. The middle panel shows blood from a mouse with a mutation in the Kras gene that causes a myeloproliferative neoplasm, with an excessive number of white blood cells and too few red blood cells. The right panel shows blood from a mutant mouse that was treated with a MEK inhibitor. This image relates to an article that appeared in the March 30, 2011, issue of Science Translational Medicine, published by AAAS. The study, by Dr. N. Lyubynska of the University of California, San Francisco in San Francisco, Calif., and colleagues, was titled, “A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice.”
Credit: Image courtesy of Benjamin Braun
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