Contact: Dr. Allan Spradling
spradling@ciwemb.edu
410-246-3021
Carnegie Institution

Mutations in Delta Lead to Tumor Formation

Caption: Mutations that disrupt the Delta protein can cause ISCs to produce many tumor cells (thin arrow, bottom) as well as a few normal enterocytes (thick arrow, top).

Credit: Image used with permission of the American Association for the Advancement of Science, Science, February 16, 2007.

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