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Unsumoylated vs. Sumoylated Alpha-Synuclein

Caption: Unsumoylated alpha-synuclein aggregates into fibrils (right), whereas sumoylated alpha-synuclein doesn't (left). New research in the Journal of Cell Biology suggests that sumoylation might prevent the protein aggregations that typify Parkinson’s disease.

Credit: Krumova, P., et al. 2011. J. Cell Biol. doi:10.1083/jcb.201010117.

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Related news release: SUMO defeats protein aggregates that typify Parkinson’s disease