Hyperactivation of AMPK in Mice with HD (image) Rockefeller University Press Caption Injection of an AMPK activator (right) increased the number of apoptotic neurons (red) in the striatum of mice with Huntington's disease (HD) compared to control cells (left). A new study in The Journal of Cell Biology describes how hyperactivation of AMPK promotes neurodegeneration in HD. Credit Ju, T.-C., et al. 2011. J. Cell Biol. doi:10.1083/jcb.201105010. Usage Restrictions Reporters may freely use these materials in news coverage, with the appropriate credit information. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.