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Hyperactivation of AMPK in Mice with HD

Caption: Injection of an AMPK activator (right) increased the number of apoptotic neurons (red) in the striatum of mice with Huntington’s disease (HD) compared to control cells (left). A new study in The Journal of Cell Biology describes how hyperactivation of AMPK promotes neurodegeneration in HD.

Credit: Ju, T.-C., et al. 2011. J. Cell Biol. doi:10.1083/jcb.201105010.

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