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Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (1 of 6)

Caption: A curaxin treated tumor cell is unable to divide. Two nuclei incompletely separated during mitosis due to the problem with chromatin in this cell. We can see extreme chromatin condensation around nucleoli ("red eyes") and punctate FACT binding throughout the nucleus (green dots). Immunofluorescent image of non-fixed cell. Red -- red fluorescent protein (RFP) tagged histone H2B. Green -- green fluorescent protein (GFP) tagged SSRP1 subunit of FACT. This image relates to a paper that appeared in the Aug. 10, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A.V. Gasparian of Cleveland BioLabs Inc. in Buffalo, N.Y., and colleagues, was titled, "Curaxins: Anticancer Compounds that Simultaneously Suppress NF-kB and Activate p53 by Targeting FACT."

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