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Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (2 of 6)

Caption: A curaxin treated tumor cell is to divide. Two nuclei incompletely separated during mitosis due to the problem with chromatin in this cell. We can see extreme chromatin condensation around nucleoli ("red eyes") and punctuate FACT binding throughout the nucleus and along nuclear membrane (yellowish structures). Immunofluorescent image of non-fixed cells. Red - red fluorescent protein (RFP) tagged histone H2B. Green - green fluorescent protein (GFP) tagged SSRP1 subunit of FACT, blue - autofluorescence of curaxin. Absence of pure blue, green and red is due to overlap of three colors (giving altogether yellowish appearance.) This image relates to a paper that appeared in the Aug. 10, 2011, 2011 issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A.V. Gasparian of Cleveland BioLabs Inc. in Buffalo, N.Y., and colleagues, was titled, "Curaxins: Anticancer Compounds that Simultaneously Suppress NF-kB and Activate p53 by Targeting FACT."

Credit: Image Science/AAAS

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