Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (2 of 6) (image) American Association for the Advancement of Science Share Print E-Mail Caption A curaxin treated tumor cell is to divide. Two nuclei incompletely separated during mitosis due to the problem with chromatin in this cell. We can see extreme chromatin condensation around nucleoli ("red eyes") and punctuate FACT binding throughout the nucleus and along nuclear membrane (yellowish structures). Immunofluorescent image of non-fixed cells. Red -- red fluorescent protein (RFP) tagged histone H2B. Green -- green fluorescent protein (GFP) tagged SSRP1 subunit of FACT, blue -- autofluorescence of curaxin. Absence of pure blue, green and red is due to overlap of three colors (giving altogether yellowish appearance.) This image relates to a paper that appeared in the Aug. 10, 2011, 2011 issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A.V. Gasparian of Cleveland BioLabs Inc. in Buffalo, N.Y., and colleagues, was titled, "Curaxins: Anticancer Compounds that Simultaneously Suppress NF-kB and Activate p53 by Targeting FACT." Credit Image © Science/AAAS Usage Restrictions Please cite the owner of the image when publishing. This image may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact Science for permission. Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.