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Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (5 of 6)

Caption: The target of curaxins, the FACT complex, is highly expressed in tumor cells, but not in normal cells. This is an enlarged image of a fragment of tissue microarray. Sections of biopsies of lung tumor (T) and normal lungs (N) of patients with lung cancer are stained with antibodies against SSRP1 subunits of FACT. FACT if target of curaxins. Brown spots are positive staining for SSRP1, located in nuclei of tumor cells (T columns), but not in normal lungs (N columns) and not in cells of stroma of tumors (T columns). Blue -– counter stain with Mayer's haematoxylin. This image relates to a paper that appeared in the Aug. 10, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. A.V. Gasparian of Cleveland BioLabs Inc. in Buffalo, N.Y., and colleagues, was titled, "Curaxins: Anticancer Compounds that Simultaneously Suppress NF-kB and Activate p53 by Targeting FACT."

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