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Caption: The lung tumor after oncogene inactivation. Oncogene inactivation induces tumor regression. Now, the lung tumor has almost completely disappeared. High-resolution CT imaging shows the very accurate measurement of a lung tumor before and after the targeted inactivation of an oncogene in an experimental model. This approach allows the ability to precisely measure the effects of potential new therapeutic drugs. Tran et al. have used these measurements to be able to model and thereby predict when shutting of a cancer gene can result in a good therapeutic response. This video relates to a paper that appeared in the Oct. 5, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. P.T. Tran of Stanford University School of Medicine in Stanford, Calif., and colleagues, was titled, "Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation."
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