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Contact: Jules Asher
NIH/National Institute of Mental Health

Expression Change, Turning Points, and Correlation Across the Lifespan

Caption: Overall gene expression plummets 5-fold in infancy and 90-fold in childhood from its prenatal peak. The decline levels-off during the middle years, but expression surges again in the last decades of life, as the brain ages. Note: The fetal/infant graph at left is based on a different scale than the lifespan graph at right, so the two are not visually comparable.

Credit: Joel Kleinman, M.D., Ph.D., NIMH Clinical Brain Disorders Branch

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