Contact: David Cameron
Harvard Medical School
Caption: Studying related proteins, researchers identified pairs of amino acid residues (left) that seemed to change in lockstep in the evolutionary record. These co-varying pairs indicated points on protein (middle) likely to be in contact after folding, giving researchers enough clues to create a computational model of the protein's three-dimensional structure (right).
Credit: Terry Helms/Memorial Sloan-Kettering Cancer Center
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