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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital

Development and Function of Innate Response Activator B Cells

Caption: The precursors of IRA-B cells, B1a B cells, reside in the peritoneal cavity. When B1a cells recognize bacteria infecting the peritoneal cavity, they migrate out of the peritoneal cavity, accumulate in the red pulp of the spleen or the bone marrow, and become IRA-B cells that secrete abundant amounts of GM-CSF. This growth factor acts on cells expressing its receptor, arming the innate immune response for efficient bacterial clearance.

Credit: Filip Swirski, Ph.D., MGH Center for Systems Biology

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