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Contact: Diana Yates
diya@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
Caption: Structure of an SEB molecule (blue) in complex with the variable region (grey with colored loops) of the T-cell receptor protein. Various amino acid residues in the loops (especially the residues colored red) were mutated to generate a protein that bound SEB with over one million-fold higher binding than the original. Soluble forms of this mutant protein were capable of neutralizing SEB in rabbit models.
Credit: Image courtesy of David M. Kranz
Usage Restrictions: Contact David M. Kranz for permission to use this image: 217 - 244-2821; d-kranz@uiuc.edu
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