New Member of the Breast-Cancer Gene Network (image) University of Pennsylvania School of Medicine Share Print E-Mail Caption Immunofluorescence in human cancer cells shows a cytoplasmic localization of Abraxas R361Q mutant (lower panel, red) while the wild type (WT) Abraxas protein is nuclear (upper panel, red). This aberrant localization decreases the ability of the protein to form nuclear foci and reduces the recruitment of BRCA1(green) to DNA breaks after ionizing irradiation. Merge of the red and green channels along with the nuclei labelled in blue highlights the cytoplasmic localization of Abraxas R361Q. Credit Roger Greenberg, PhD, Perelman School of Medicine, University of Pennsylvania; Science Translational Medicine Usage Restrictions None Share Print E-Mail Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.