Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Possible New Breast Cancer Gene

Caption: Upper panels: BRCA1 and Rap80 are recruited to the same structures at DNA damage sites in human cells treated with ionizing radiation. The merge panel is a digital overlay of the BRCA1 and Rap80 panels. Each circle represents a nucleus within one cell. Lower panels: Rap80 targets BRCA1 to DNA damage sites. Depletion of Rap80 from human cells (right panels) reduces the ability of BRCA1 to migrate to laser-induced DNA damage sites as compared to control (ct) cells (left panels).

Credit: Science, Sobhian et al. 2007

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